Liocaine^® is a local anesthetic of the amide type, provides prompt and profound anesthesia of mucous membranes and lubrication which reduces friction, giving effective anesthesia of long duration (approx. 20-30 min). Anesthesia usually occurs rapidly (within 5 min, depending upon the area of application).

 -Therapeutic Indications

Liocaine^® is indicated for:

-As a surface anesthetic and lubricant for:

-   The male and female urethra during cystoscopy, catheterization, exploration by sound and other endourethral procedures.

-   Nasal and pharyngeal cavities in endoscopic procedures such as gastroscopy and bronchoscopy.

-   During proctoscopy and rectoscopy

-   Tracheal intubation

-   Symptomatic treatment of pain in connection with cystitis and urethritis. -To relieve pain after circumcision in children.

 Do not use Liocaine:  

- if You  are hypersensitive to Lidocaine, other local anesthetics of the amide type, or any component of this product.

- Take special care with Liocaine:

•  You should be adhered strictly to the recommended dosage, Since the excessive doses of lidocaine or short intervals between doses can result in high plasma levels and serious side effects. 
• You should be used lidocaine with caution when applied to traumatized mucosa and/or sepsis regions, Since the absorption from wound surfaces and mucous membranes is relatively high and especially high in the bronchial tree.
• If you from patients with partial or complete heart block, elderly or if you in poor general health and / or with advanced liver disease or severe renal dysfunction ; the dose or administration is likely to result in high blood levels, You require special attention to prevent potentially dangerous side effects.
• The oropharyngeal use of topical anesthetics may interfere with swallowing and enhance the danger of aspiration. Numbness of the tongue or buccal mucosa may increase the danger of biting trauma.
• When used for endotracheal tube lubrication, care should be taken to avoid introduction of the gel into the lumen of the tube. The gel may dry on the inner surface leaving a residue which tends to clump with flexion, narrowing the lumen. There have been rare reports in which this residue has caused the lumen to occlude.

-Taking other medicines:

•  Lidocaine should be used with caution in patients receiving agents structurally related to local anesthetics, since the toxic effects are additive.
•  Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. 

-Pregnancy and breast-feeding:

-   Pregnancy: Category B; no specific disturbances to the reproductive process have been reported.

-    Lactation: Lidocaine may enter the mother’s milk, but such in small amounts that there is generally no risk of this affecting the neonate.

Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breast-feeding.

- Driving and using machines

-  Effects on ability to drive and use machines depending on the dose, local anesthetics may have a very mild effect on mental function and may temporarily impair locomotion and coordination.

Always use Liocaine exactly as your doctor has told you.  You should check with your doctor or pharmacist if you are not sure.

-The usual dose is: 

-   Debilitated or elderly patients, children over 12 years of age, acutely ill patients or patients with sepsis should be given doses commensurate with their age, weight and physical condition.

-   No more than four doses should be given in a 24 hour period.

-   The dose should not exceed 4.5 mg/kg in children below 12 years old.

-    The following dose recommendation should be regarded as a guide. The clinician’s experience and the patient’s physical status are important in calculating the required dose:

Urethral anesthesia:

-  Surface anesthesia of the male adult urethra: 6-11 ml of the gel is required. The gel is instilled slowly until the patient has a feeling of tension. A penile clamp is then applied for several minutes at the corona, after which the rest of the jelly is instilled. When anesthesia is especially important, e.g., during sounding or cystoscopy, Start a dose of 6-11ml; further instillation of 6-11ml may be required and allowed to act for 10 minutes before the insertion of the instrument. The gel could also be instilled into the bladder for procedures in this region.

-  Surface anesthesia of the female adult urethra: 5-10 ml of the gel is instilled in small portions to fill the urethra, then waiting several minutes prior performing urological procedures Endoscopy:

-  6-11 ml of the gel is instilled and a small amount may be applied to the lubricating instrument.

Lubrication for endotracheal intubation:

-  About 2 ml applied to the surface of the tube just prior to insertion. The gel should not be introduced into the lumen of the tube.

-   If you use more Liocaine than you should: 

Toxic reactions originate mainly in the central nervous system and the cardiovascular system after an overdose. Treatment of acute toxicity should be instituted at the latest when twitches occur. The objectives of treatment are to maintain oxygenation; stop the convulsions and support the circulation If you have any further questions on the use of this product, ask your doctor or pharmacist. 

Like all medicines, Liocaine can cause side effects, although not everybody gets them.

The side effects are: 

• Following endotracheal tube lubrication, an increased incidence of postoperative sore throat has been reported. Allergic reactions are rare.
• If high systemic levels of lidocaine occur due to fast absorption or overdose, acute toxic effects may develop.
• If you get side effects and they become serious or if you notice any other side effects not listed in this leaflet, please tell your doctor or pharmacist.

- K=                - Keep out of the reach and sight of children.

- Store below 30 C 

- Do not use Liocaine after the expiry date which is stated on the label.  The expiry date refers to the last day of that month.

- Do not use the Liocaine  if you notice that the tube seal is broken or missing. -Medicines should not be disposed of via wastewater or household waste.   Ask your pharmacist how to dispose of medicines no longer required.  These  measures will help protect the environment.