Lisino™ contains a medicine called lisinopril. This belongs to a group of medicines
called ACE inhibitors.
Lisino™ can be used for the following conditions:
• To treat high blood pressure (hypertension).
• To treat heart failure.
• If you have recently had a heart attack (myocardial infarction).
• To treat kidney problems caused by Type II diabetes in people with high blood
pressure.
Lisino™ works by making your blood vessels widen. This helps to lower your blood
pressure. It also makes it easier for your heart to pump blood to all parts of your body.

Do not take Lisino™ if:
• You are allergic (hypersensitive) to lisinopril or any of the other ingredients of
LisinoTM (listed in Section 6: Further information).
• You have ever had an allergic reaction to another ACE inhibitor medicine. The
allergic reaction may have caused swelling of the hands, feet, ankles, face, lips,
tongue or throat. It may also have made it difficult to swallow or breathe
(angioedema).
• A member of your family has had severe allergic reactions (angioedema) to an ACE
inhibitor or you have had severe allergic reactions (angioedema) without a known
cause.
• If you are more than 3 months pregnant. (It is also better to avoid LisinoTM in early
pregnancy - see Pregnancy section).
Do not take Lisino™ if any of the above applies to you. If you are not sure, talk to your
doctor or pharmacist before taking Lisino™.
If you develop a dry cough which is persistent for a long time after starting treatment
with Lisino™, talk to your doctor.
Take special care with Lisino™
Check with your doctor or pharmacist before taking Lisino™ if:
• You have a narrowing (stenosis) of the aorta (an artery in your heart) or a narrowing
of the heart valves (mitral valves).
• You have a narrowing (stenosis) of the kidney artery.
• You have an increase in the thickness of the heart muscle (known as hypertrophic
cardiomyopathy).
• You have problems with your blood vessels (collagen vascular disease).
• You have low blood pressure. You may notice this as feeling dizzy or light-headed,
especially when standing up.
• You have kidney problems or you are having kidney dialysis.
• You have liver problems.
• You have diabetes.
• You have recently had diarrhoea or vomiting (being sick).
• Your doctor has told you to control the amount of salt in your diet.
• You have high levels of cholesterol and you are having a treatment called ‘LDL
apheresis’.
• You must tell your doctor if you think you are (or might become) pregnant. LisinoTM
is not recommended in early pregnancy, and must not be taken if you are more than 3
months pregnant, as it may cause serious harm to your baby if used at that stage (see
Pregnancy section).
• You are of black origin as Lisino™ may be less effective. You may also more readily
get the side effect ‘angioedema’ (a severe allergic reaction).
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist
before taking Lisino™.
Treatment for allergies such as insect stings
Tell your doctor if you are having or are going to have treatment to lower the effects
of an allergy such as insect stings (desensitisation treatment). If you take Lisino™
while you are having this treatment, it may cause a severe allergic reaction.
Operations
If you are going to have an operation (including dental surgery) tell the doctor or
dentist that you are taking Lisino™. This is because you can get low blood pressure
(hypotension) if you are given certain local or general anaesthetics while you are
taking Lisino™.
Taking other medicines
Tell your doctor if you are taking, or have recently taken, any other medicines. This
includes medicines that you buy without a prescription. This is because Lisino™ can
affect the way some medicines work and some medicines can have an effect on
Lisino™.
In particular, tell your doctor or pharmacist if you are taking any of the following
medicines:
• Other medicines to help lower your blood pressure.
• Water tablets (diuretic medicines).
• Medicines to break up blood clots (usually given in hospital).
• Beta-blocker medicines, such as atenolol and propranolol.
• Nitrate medicines (for heart problems).
• Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and arthritis.
• Aspirin (Acetylsalicylic acid), if you are taking more than 3 grams each day.
• Medicines for depression and for mental problems, including lithium.
• Potassium tablets or salt substitutes that have potassium in them.
• Insulin or medicines that you take by mouth for diabetes.
• Medicines used to treat asthma.
• Medicines to treat nose or sinus congestion or other cold remedies (including those
you can buy in the pharmacy).
• Medicines to suppress the body’s immune response (immunosuppressants).
• Allopurinol (for gout).
• Procainamide (for heart beat problems).
• Medicines that contain gold, such as sodium aurothiomalate, which may be given to
you as an injection.
Pregnancy and breast-feeding
Pregnancy:
You must tell your doctor if you think you are (or might become) pregnant. Your
doctor will normally advise you to stop taking Lisino™ before you become pregnant or
as soon as you know you are pregnant and will advise you to take another medicine
instead of Lisino™. Lisino™ is not recommended in early pregnancy, and must not be
taken when more than 3 months pregnant, as it may cause serious harm to your baby if
used after the third month of pregnancy.
Breast-feeding:
Tell your doctor if you are breast-feeding or about to start breast-feeding. Lisino™ is
not recommended for mothers who are breast-feeding, and your doctor may choose
another treatment for you if you wish to breast-feed, especially if your baby is
newborn, or was born prematurely.
Driving and using machines
• Some people feel dizzy or tired when taking this medicine. If this happens to you, do
not drive or use any tools or machines.
• You must wait to see how your medicine affects you before trying these activities.
Important information about the ingredients of Lisino™
These tablets contain lactose. If you have an intolerance to some sugars, please speak
to your pharmacist or doctor before taking this medicine.

Always take Lisino™ exactly as your doctor has told you. You should check with your
doctor or pharmacist if you are not sure.
Once you have started taking Lisino™ your doctor may take blood tests. Your doctor
may then adjust your dose so you take the right amount of medicine for you.
Taking your medicine
• Swallow the tablet with a drink of water.
• Try to take your tablets at the same time each day. It does not matter if you take
Lisino™ before or after food.
• Keep taking Lisino™ for as long as your doctor tells you to, it is a long term
treatment. It is important to keep taking LisinoTM every day.
Taking your first dose
• Take special care when you have your first dose of Lisino™ or if your dose is
increased. It may cause a greater fall in blood pressure than later doses.
• This may make you feel dizzy or light-headed. If this happens, it may help to lie
down. If you are concerned, please talk to your doctor as soon as possible.
Adults
Your dose depends on your medical condition and whether you are taking any other
medicines. Your doctor will tell you how many tablets to take each day. Check with
your doctor or pharmacist if you are unsure.
For high blood pressure
• The usual starting dose is 10 mg once a day.
• The usual long-term dose is 20 mg once a day.
For heart failure
• The usual starting dose is 2.5 mg once a day.
• The long-term dose is 5 to 35 mg once a day.
After a heart attack
• The usual starting dose is 5 mg within 24 hours of your attack and 5 mg one day
later.
• The usual long-term dose is 10 mg once a day.
For kidney problems caused by diabetes
• The usual dose is either 10 mg or 20 mg once a day.
If you are elderly, have kidney problems or are taking diuretic medicines your doctor
may give you a lower dose than the usual dose.
Children and adolescents (6 to 16 years old) with high blood pressure
• LisinoTM is not recommended for children under 6 years or in any children with
severe kidney problems.
• The doctor will work out the correct dose for your child. The dose depends on the
child’s body weight.
• For children who weigh between 20 kg and 50 kg, the usual starting dose is 2.5 mg
once a day.

• For children who weigh more than 50 kg, the usual starting dose is 5 mg once a day.
If you take more Lisino™ than you should
If you take more Lisino™ than prescribed by your doctor, talk to a doctor or go to a
hospital immediately. The following effects are most likely to happen: Dizziness,
palpitations.
If you forget to take Lisino™
• If you forget to take a dose, take it as soon as you remember. However, if it is nearly
time for the next dose, skip the missed dose.
• Do not take a double dose to make up for a forgotten dose.
If you stop taking Lisino™
Do not stop taking your tablets, even if you are feeling well, unless your doctor tells
you to.
If you have any further questions on the use of this medicine, ask your doctor or
pharmacist.
 

Like all medicines, Lisino™ can cause side effects, although not everybody gets them.
If you experience any of the following reactions, stop taking Lisino™ and see your
doctor immediately:
• Severe allergic reactions (rare, affects 1 to 10 users in 10,000). The signs may
include sudden onset of:
- Swelling of your face, lips, tongue or throat. This may make it difficult to swallow.
- Severe or sudden swelling of your hands, feet and ankles.
- Difficulty breathing.
- Severe itching of the skin (with raised lumps).
• Severe skin disorders, like a sudden, unexpected rash or burning, red or peeling skin
(very rare, affects less than 1 user in 10,000).
• An infection with symptoms such as fever and serious deterioration of your general
condition, or fever with local infection symptoms such as sore throat/pharynx/mouth
or urinary problems (very rare, affects less than 1 user in 10,000).
Other possible side effects:
Common (affects 1 to 10 users in 100)
• Headache.
• Feeling dizzy or light-headed, especially if you stand up quickly.
• Diarrhoea.
• A dry cough that does not go away.
• Being sick (vomiting).
• Kidney problems (shown in a blood test).
Uncommon (affects 1 to 10 users in 1,000)
• Mood changes.
• Change of colour in your fingers or toes (pale blue followed by redness) or numbness
or tingling in your fingers or toes.
• Changes in the way things taste.
• Feeling sleepy.
• Spinning feeling (vertigo).
• Having difficulty sleeping.
• Stroke.
• Fast heart beat.
• Runny nose.
• Feeling sick (nausea).
• Stomach pain or indigestion.
• Skin rash or itching.
• Being unable to get an erection (impotence).
• Feeling tired or feeling weak (loss of strength).
• A very big drop in blood pressure may happen in people with the following
conditions: coronary heart disease; narrowing of the aorta (a heart artery), kidney
artery or heart valves; an increase in the thickness of the heart muscle. If this happens
to you, you may feel dizzy or light-headed, especially if you stand up quickly.
• Changes in blood tests that show how well your liver and kidneys are working.
• Heart attack.
Rare (affects 1 to 10 users in 10,000)
• Feeling confused.
• A lumpy rash (hives).
• Dry mouth.
• Hair loss.
• Psoriasis (a skin problem).
• Changes in the way things smell.
• Development of breasts in men.
• Changes to some of the cells or other parts of your blood. Your doctor may take
blood samples from time to time to check whether LisinoTM has had any effect on your
blood. The signs may include feeling tired, pale skin, a sore throat, high temperature
(fever), joint and muscle pains, swelling of the joints or glands, or sensitivity to
sunlight.
• Low levels of sodium in your blood (the symptoms may be tiredness, headache,
nausea, vomiting).
• Sudden renal failure.
Very rare (affect less than 1 user in 10,000)
• Sinusitis (a feeling of pain and fullness behind your cheeks and eyes).
• Wheezing.
• Low levels of sugar in your blood (hypoglycaemia). The signs may include feeling
hungry or weak, sweating and a fast heart beat.
• Inflammation of the lungs. The signs include cough, feeling short of breath and high
temperature (fever).
• Yellowing of the skin or the whites of the eyes (jaundice).
• Inflammation of the liver. This can cause loss of appetite, yellowing of the skin and
eyes, and dark coloured urine.
• Inflammation of the pancreas. This causes moderate to severe pain in the stomach.
• Severe skin disorders. The symptoms include redness, blistering and peeling.
• Sweating.
• Passing less water (urine) than normal or passing no water.
• Liver failure.
• Lumps.
• Inflamed gut.
Not known (frequency cannot be estimated from available data)
• Symptoms of depression.
• Fainting.
Side effects in children appear to be comparable to those seen in adults.
If any of the side effects get serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.

• Keep out of the reach and sight of children.
• Do not store above 30 ºC.
• Do not use after the expiry date (EXP) which is stated on the blister strip and the
carton.
• Medicines should not be disposed of via waste water or household waste. Ask your
pharmacist how to dispose of medicines no longer required. This will help to protect
the environment.