The name of this medicine is:
10%, 20% Mannitol Solution for Infusion
In this leaflet it is jointly referred to as Mannitol infusion.
Mannitol infusion is used as an osmotic diuretic. Diuretics increase the amount of urine
passed, which causes the body to lose water and salt.
Your doctor will be able to explain this to you.
Mannitol infusion is used on its own or to supplement the action of other diuretics in order to
treat or prevent kidney failure and help get rid of toxic substances from the body by
increasing urine flow.
Mannitol also promotes the excretion of substances such as aspirin and barbiturates (drugs
used in treatment of sleeping problems).
Mannitol infusion is given by intravenous (into a vein) infusion.

You should not receive Mannitol infusion if
• You are allergic (hypersensitive) to mannitol or any of the ingredients of Mannitol infusion
mentioned in Section 6.
• You have abnormally fragile blood vessels (capillary fragility)
• You have fluid on the lungs (pulmonary congestion or pulmonary oedema)
• You have bleeding inside your head (intracranial bleeding)
• You have heart failure
• You have kidney failure (unless a test dose has produced a diuretic response)

Warnings and precautions
Care should be taken when being administered with Mannitol infusion
• Tell your doctor if you suffer from abnormal fluid retention in your body cells (called
edematous conditions) associated with reduced heart function.
• Mannitol infusion should be administered to you slowly and should not be mixed with
blood. Your doctor or nurse will make sure the infusion is given to you correctly.
• Kidney cells may be damaged if mannitol is administered simultaneously.
Your doctor or nurse will ensure the solution is clear and free from any particles before use.
Your doctor may monitor your salt and fluid levels during treatment.
Other Medicines and Mannitol infusion
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other
medicines.
Inform your doctor if you take or have recently taken any of the below medicines:
• Tubocurarine (a medicine used during anesthesia)
• Cyclosporin (used in organ transplantation)
• Electrolyte solutions (salts)
• Corticotrophin (a hormone)
• Barbiturates (sleeping medicines or anaesthetics)
• Noradrennaline (a hormone)
• Metaraminol (a medicine used if you have very low blood pressure)
• Suxamethonium (a muscle relaxant)
• Tetracyclines (antibiotics)
Taking Mannitol infusion with food and drink
Mannitol infusion has no effect with food and drink

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a
baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
Mannitol infusion has no effect on driving or using machines.

Mannitol infusion must only be given to you in a hospital by healthcare professionals
You will receive your medicine by infusion (IV drip).
Dosage
Your doctor will decide on the correct dose for you to receive.
The amount and rate at which the infusion is given depends on your requirements.
Adults and Children
Usual dose up to 50 g on one occasion, the infusion should be given noting the urine
excretion rate does not exceed 100ml/hour.
Elderly
Elderly patients are more likely to be affected by the side effects associated with mannitol.
This is due to diminished kidney function and heart capacity
You should therefore be given a test dose as described below for patients with any kidney impairment.
Kidney Impairment
If you have reduced kidney function you should be given a test dose of 200 mg per
kilogram body weight administered to you over five minutes. If your body produces 40 ml or
more of urine within an hour, mannitol may then be given to you in smaller doses.
If you receive more Mannitol infusion than you should
It is very unlikely that you will receive more infusion than you should.
If you suspect an over dosage with mannitol you should look for the symptoms/side effects
described below in this leaflet.
You should immediately inform your doctor describing the symptoms.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines Mannitol infusion can cause side effects, although not everybody gets them.
All medicines can cause allergic reactions although serious allergic reactions are very rare.
If you get any of the following symptoms after receiving this medicine, you should contact
your doctor immediately:
• Nausea
• Vomiting
• Upper abdomen discomfort
• Headache
• Confusion
• Cramps
• Tachycardia (an increase in heart rate)
• Skin Rash
• Swelling
Rapid intravenous infusion of mannitol may produce:
• Headache
• Chills
• Chest pain
• Breathing difficulties
• Convulsions (fits)
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side
effects not listed in this leaflet.
By reporting side effects, you can help provide more information on the safety of this medicine.

Do not store above 30°C.
Keep out of the sight and reach of children.
Your doctor and hospital pharmacist are responsible for the correct storage, use and
disposal of Mannitol infusion.
The solution must not be used after the expiry date shown on the label. The expiry date
refers to the last day of that month.
Any solution remaining after treatment should be disposed of using the approved hospital procedures.
The solution should not be diluted before use.