This medicine is provided as a vaginal tablet that contains the natural female sex hormone progesterone. ENDOMETRIN is for women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) programme.
Progesterone acts on the lining of the womb and it helps you to become and to stay pregnant when you are treated for infertility.

ENDOMETRIN can be used only in women who are undergoing infertility treatment in an Assisted Reproductive Technology (ART) programme. The treatment is started on the day of egg retrieval.
Your doctor will tell you when the treatment is started.
Do not use ENDOMETRIN
• if you are allergic to progesterone or any of the other ingredients of this medicine.
• if you have unusual vaginal bleeding that has not been evaluated by the doctor.
• if you have a miscarriage and your physician suspects some tissue is still in the uterus or pregnancy outside of the womb.
• if you currently have or have had severe liver problems.
• if you have known or suspected breast or genital tract cancer.
• if you have or have had blood clots in the legs, lungs, eyes or elsewhere in the body.
• if you have porphyria disorders (a group of inherited or acquired disorders of certain enzymes).
Warnings and precautions
Take special care and tell your doctor straight away if you experience any of these symptoms during treatment or even few days after the last dosage:
• pains in the calves or chest, a sudden shortness of breath or coughing blood indicating possible clots in the legs, heart, or lungs
• severe headache or vomiting, dizziness, faintness, or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye
• worsening symptoms of depression
Before treatment with ENDOMETRIN tell your doctor if you have had or have any of the following health problems: Epilepsy, Migraine, Asthma, Cardiac or renal dysfunction, Diabetes.
Children: There is no relevant use of ENDOMETRIN in children.
Other medicines and ENDOMETRIN
Tell your doctor if you are using, have recently used or might use any other medicines. Some medicines may interact with vaginal progesterone tablets.
For example, carbamazepine, rifampicine as well as St. John’s wort-containing herbal products may decrease the effectiveness, whereas products containing ketoconazole and vaginal antifungal creams may alter the actions of progesterone.
Pregnancy and breast-feeding
ENDOMETRIN can be used during the first trimester of pregnancy for women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) programme.
The risks of congenital (conditions present at birth) anomalies, including genital abnormalities in male or female infants, from exposure to exogenous progesterone during pregnancy have not been fully established.
This medicine should not be used during breast feeding.
Driving and using machines: ENDOMETRIN has minor or moderate influence on the ability to drive and use machines. It may cause drowsiness and/or dizziness; therefore caution is advised in drivers and users of machines.

Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure.
The dose of ENDOMETRIN is 100 mg administered vaginally two or three times daily starting the day after oocyte retrieval and continuing for up to 10 weeks total duration.
Instructions for use
ENDOMETRIN is to be placed directly into your vagina by the applicator provided.
1. Unwrap the applicator.
2. Put one tablet in the space provided at the end of the applicator. The tablet should fit securely and not fall out.

3. The applicator with the tablet may be inserted into the vagina while you are standing, sitting, or when lying on your back with your knees bent. Gently insert the thin end of the applicator well into the vagina.
4. Push the plunger to release the tablet.
Remove the applicator and rinse it thoroughly in warm running water, wipe dry with a soft tissue and keep the applicator for subsequent use.

If you use more ENDOMETRIN than you should
Please consult your doctor or pharmacist if you have used more ENDOMETRIN than your doctor has told you.
If you forget to use ENDOMETRIN
Take the dose as soon as you remember and then carry on as before. Do not take a double dose to make up for a forgotten dose.
If you stop using ENDOMETRIN
Please consult your doctor or pharmacist for advice if you intend to stop or have stopped using ENDOMETRIN. Abrupt discontinuation of progesterone dosing may cause increased anxiety, moodiness, and increased sensibility to seizures.

Like all medicines, this medicine can cause side effects, although not everybody gets them.The most common side effects are headache, vaginal disorders and uterine cramping.
The following common side effects affect between 1 and 10 of every 100 patients treated:- Headache, Abdominal distension (swelling in the abdomen), Abdominal pain, Nausea, Uterine cramping
The following uncommon side effects affect between 1 and 10 of every 1000 patients treated: Dizziness, Insomnia, Diarrhoea, Constipation, Urticaria (allergic rash), Rash, Vaginal disorders (e.g. pain, burning sensation, discharge, dryness, and bleeding), Fungal
infection in vagina, Breast disorders (e.g. breast pain, breast swelling and breast tenderness), Itching in the genital area, Peripheral edema (swelling due to the build up of fluid),
The following side effects have been seen after the product was marketed. Frequency is not known (cannot be estimated from the available data): Fatigue, Vomiting, Allergic reactions.

Store in the original container and at temperature below 30°C.
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.