Klavox is an antibiotic and works by killing bacteria that cause infections. It contains two
different medicines called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of
medicines called “penicillins” that can sometimes be stopped from working (made inactive). The
other active component (clavulanic acid) stops this from happening.
Klavox is used in adults and children to treat the following infections:
• Middle ear and sinus infections,
• Respiratory tract infections,
• Urinary tract infections,
• Skin and soft tissue infections including dental infections,
• Bone and joint infections.

Do not take Klavox:

● If you are allergic (hypersensitive) to amoxicillin, clavulanic acid, penicillin or any of the
other ingredients of Klavox (listed in section 6)
● If you have ever had a severe allergic (hypersensitive) reaction to any other antibiotic.
This can include a skin rash or swelling of the face or neck
● If you have ever had liver problems or jaundice (yellowing of the skin) when taking an
antibiotic
Do not take Klavox if any of the above apply to you. If you are not sure, talk to your doctor or
pharmacist before taking Klavox.
Take special care with Klavox
Talk to your doctor or pharmacist before taking this medicine if you:
● Have glandular fever
● Are being treated for liver or kidney problems
● Are not passing water regularly
Abnormal prolongation of prothrombin time (increased INR) has been reported rarely in patients
receiving amoxicillin and oral anticoagulants. Appropriate monitoring should be undertaken
when anticoagulants are prescribed concurrently. Adjustments in the dose of oral anticoagulants
may be necessary to maintain the desired level of anticoagulation.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before
taking Klavox.
In some cases, your doctor may investigate the type of bacteria that is causing your infection.
Depending on the results, you may be given a different strength of Klavox or a different
medicine.
Conditions you need to look out for Klavox can make some existing conditions worse, or cause
serious side effects. These include allergic reactions, convulsions (fits) and inflammation of the
large intestine. You must look out for certain symptoms while you are taking Klavox, to reduce
the risk of any problems. See ‘Conditions you need to look out for’ in Section 4.
Blood and urine tests
If you are having blood tests (such as red blood cell status tests or liver function tests) or urine
tests (for glucose), let the doctor or nurse know that you are taking Klavox. This is because
Klavox can affect the results of these type of tests.
Using other medicines
Please tell your doctor or pharmacist if you are using or have recently used any other medicines.
This includes medicines that can be bought without a prescription.
● If you are taking allopurinol (used for gout) with Klavox, it may be more likely that
you’ll have an allergic skin reaction.
● If you are taking probenecid (used for gout), your doctor may decide to adjust your dose
of Klavox.
● If medicines to help stop blood clots (such as warfarin) are taken with Klavox then extra
blood tests may be needed.
● In the literature there are rare cases of increased international normalised ratio in patients
maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If coadministration
is necessary, the prothrombin time or international normalised ratio should

be carefully monitored with the addition or withdrawal of amoxicillin (see 2. Before you
take Klavox).
● Klavox can affect how methotrexate (a medicine used to treat cancer or rheumatic
diseases) works.
● Klavox can affect how mycophenolate mofetil (a medicine used to prevent the rejection
of transplanted organs) works.
Pregnancy and breast-feeding
If you are pregnant, you think you might be pregnant or if you are breast-feeding, please tell your
doctor or pharmacist.
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Klavox can have side effects and the symptoms may make you unfit to drive.
Don’t drive or operate machinery unless you are feeling well.

Always take Klavox exactly as your doctor has told you. You should check with your doctor or
pharmacist if you are not sure.
Adults and children weighing 40 kg and over
The usual doses are:
● 1 tablet of Klavox 625 mg three times daily.
Children weighing less than 40 kg
Children aged 6 years or less should preferably be treated with Klavox suspension.
Ask your doctor or pharmacist for advice when giving Klavox tablets to children weighing less
than 40 kg. The tablets are not suitable for children weighing less than 25 kg.
Patients with kidney and liver problems
● If you have kidney problems the dose might be changed. A different strength or a
different medicine may be chosen by your doctor.
● If you have liver problems you may have more frequent blood tests to see how your liver
is working.
How to take Klavox
● Swallow the tablet whole with a glass of water at the start of a meal or slightly before.
● Do not take Klavox for more than 2 weeks. If you still feel unwell you should go back to
see the doctor.
If you take more Klavox than you should
If you have too much Klavox, signs might include an upset stomach (feeling sick, being sick or
diarrhoea) or convulsions. Talk to your doctor as soon as possible. Take the medicine carton to
show the doctor.
If you forget to take Klavox
● If you forget to take a dose, take it as soon as you remember.
● You should not take the next dose too soon, but wait about 4 hours before taking the next
dose.
● Do not take a double dose to make up for a forgotten dose.

If you stop taking Klavox
Keep taking Klavox until the treatment is finished, even if you feel better. You need every dose
to help fight the infection. If some bacteria survive they can cause the infection to come back.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines, Klavox can cause side effects, although not everybody gets them.
Conditions you need to look out for Allergic reactions:
● Skin rash.
● Inflammation of blood vessels (vasculitis) which may be visible as red or purple raised
spots on the skin, but can affect other parts of the body.
● Fever, joint pain, swollen glands in the neck, armpit or groin.
● Swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing.
● collapse
Contact a doctor immediately if you get any of these symptoms. Stop taking Klavox.
Inflammation of large intestine
Inflammation of the large intestine, causing watery diarrhoea usually with blood and mucus,
stomach pain and/or fever.
Contact your doctor as soon as possible for advice if you get these symptoms.
Very common side effects
These may affect more than 1 in 10 people
● Diarrhoea (in adults).
Common side effects
These may affect up to 1 in 10 people
● Thrush (candida - a yeast infection of the vagina, mouth or skin folds)
● Feeling sick (nausea), especially when taking high doses
If affected take Klavox before food
● Vomiting
● Diarrhoea (in children).
Uncommon side effects
These may affect up to 1 in 100 people
● Skin rash, itching
● raised itchy rash (hives)
● Indigestion
● Dizziness
● Headache.
Uncommon side effects that may show up in your blood tests:
● Increase in some substances (enzymes) produced by the liver.
Rare side effects
These may affect up to 1 in 1000 people
● Skin rash, which may blister, and looks like small targets (central dark spots surrounded
by a paler area, with a dark ring around the edge – erythema multiforme)
If you notice any of these symptoms contact a doctor urgently.
Rare side effects that may show up in your blood tests:
● Low number of cells involved in blood clotting

● Low number of white blood cells.
Other side effects
Other side effects have occurred in a very small number of people but their exact frequency is
unknown.
● Allergic reactions
● Inflammation of the large intestine
● Prolongation of bleeding time and prothrombin time (see 2. Before you take Klavox).
● Inflammation of the protective membrane surrounding the brain (aseptic meningitis)
● Serious skin reactions:
- a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and
genitals (Stevens-Johnson syndrome), and a more severe form, causing extensive peeling of the
skin (more than 30% of the body surface – toxic epidermal necrolysis)
- Widespread red skin rash with small pus-containing blisters (bullous exfoliative dermatitis)
- A red, scaly rash with bumps under the skin and blisters (exanthemous pustulosis)
Contact a doctor immediately if you get any of these symptoms.
● Inflammation of the liver (hepatitis)
● Jaundice, caused by increases in the blood of bilirubin (a substance produced in the liver)
which may make your skin and whites of the eyes appear yellow
● Inflammation of the kidney
● Blood takes longer to clot
● Hyperactivity
● Convulsions (in people taking high doses of Klavox or who have kidney problems)
● Black tongue which looks hairy
Side effects that may show up in your blood or urine tests:
● Severe reduction in the number of white blood cells
● Low number of red blood cells (haemolytic anaemia)
● Crystals in urine.
If any of the side effects become severe or troublesome, or if you notice any side effects not
listed in this leaflet. Tell your doctor or pharmacist.

● Keep out of the reach and sight of children.
● Do not use Klavox after the expiry date which is stated on the carton. The expiry date
refers to the last day of that month.
● Store in a dry place below 25°C.
● Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help to
protect the environment.