1- WHAT AMISTOP IS AND WHAT IT IS USED FOR
AMISTOP suspension contains domperidone which is a dopamine antagonist with
anti-emetic effect.
AMISTOP suspension used in treatment of:
Epigastric sense of fullness, early satiety, felling of abdominal distension, upper
abdominal pain and heart burn.
Nausea and vomiting specially related to radiotherapy or drug therapy (e.g. L-dopa
and bromocriptine that used in Parkinson's disease).

2- BEFORE YOU TAKE AMISTOP
Domperidone may be associated with an increased risk of heart rhythm disorder and
cardiac arrest. This risk may be more likely in those over 60 years or taking doses
higher than 30 mg per day.
A-Do not takes AMISTOP:
- If you are allergic to domperidone or any component of this drug.
- If you are suffering from prolactinoma (Prolactin-releasing pituitary tumour).
- If you are suffering from gastro-intestinal hemorrhage.
- If you are suffering from mechanical obstruction or perforation.
- If stimulation of the gastric motility will be harmful to you.
B-Take special care with AMISTOP
Check with your physician or pharmacist before using this medicine:
- If you suffers from hepatic and renal problems.
- If you use inhibitors of CYP3A4.
- If you are pregnant and lactating women.
C-Taking other medicines, herbal or dietary supplements
- Inhibitors of CYP3A4 like oral ketoconazole and erythromycin may be increase
plasma level of domperidone.
- Anti-cholinergic drugs may reduce effect of domperidone.
- Antacids may decrease oral bioavailability of domperidone
Please tell your physician or pharmacist if you are taking or have recently taken any
other medicines, including medicines obtained without prescription.
D-Taking AMISTOP with food and drink
It is recommended to take AMISTOP suspension before meals.
If taken after meals, absorption of the drug may be delayed.
E-Pregnancy
Ask your physician or pharmacist for advice before taking any medicine.
There are limited data about the use of domperidone in pregnancy. Therefore,
AMISTOP suspension should only be used during pregnancy when justified by the
anticipated therapeutic benefit.
F- Breastfeeding
Domperidone excreted in breast milk in small quantity. There are limited data about
the effect of domperidone on newborn. Therefore, AMISTOP suspension is not
recommended to use during lactation.
Ask your physician or pharmacist for advice before taking any medicine.
G- Driving and using machines
AMISTOP suspension has no effect on driving or using machines.
H- Important information about some of the ingredients of AMISTOP:
- AMISTOP suspension contains E216 and E218 that may cause allergic reactions.
- AMISTOP suspension contains E420. It’s not recommended to use in patients with
hereditary sugar intolerance.

3- HOW TO TAKE AMISTOP
Always take AMISTOP suspension exactly as your physician has told you.
You should check with your physician or pharmacist if you are not sure.
Shake the bottle before use
Dosage
Your physician will determine what dose is appropriate for you.
- For chronic dyspepsia:
Adults: 10 ml three to four times daily.(maximum daily dose is 80 ml)
Children: 2.5 ml/10kg body weight, three to four times daily.
- For treatment of nausea and vomiting:
Adults: 20 ml three to four times daily at bed time.
Children: 5.0 ml/10kg body weight, three to four times daily at bed time.
It is recommended to take AMISTOP suspension for four weeks then re-evaluation
of patients Conditions.
If you take more AMISTOP than you should:
Call your physician or go to the nearest hospital emergency unit immediately.
Overdose occurs mainly in infants and children. Symptoms includes: convulsions,
agitation, disorientation and somnolence.
Treatment: There is no specific antidote to domperidone. Gastric lavage and
administration of activated charcoal are recommended with immediate medical
supervision.
If you forget to take AMISTOP:
Take the missed dose as soon as you remember.
Skip the missed dose if it is almost time for your next scheduled dose. Do not use
extra medicine to make up the missed dose.
If you stop taking AMISTOP SUSPENSION:
Do not stop taking AMISTOP unless your physician tells you to.
If you have any further questions on the use of this product, ask your physician or
pharmacist.

4- POSSIBLE SIDE EFFECTS
Like all medicines, AMISTOP can cause side effects, although not everybody gets them .
Tell your physician immediately if you experience any of the following symptoms:
AMISTOP may cause some of the following side effects: Ventricular arrhythmia,
amenorrhea, galactorrhoea, gynaecomastia, agitation and nervousness Allergic
reaction, anaphylactic shock or angioedema, transient intestinal cramps, abnormal
liver functions, convulsions, somnolence, headache, skin rash and ulcers.
If any of the side effects gets serious, or if you notice any side effects not listed in
this leaflet, please tell your physician or pharmacist

5- HOW TO STORE AMISTOP
- Store below 30° C.
- Keep away from light.
- Keep out of reach of children.
- To be used within one month after first opening.
- Store in the original container.
Do not use AMISTOP after the expiry date which is stated on the box.
The expiry date refers to the last day of that month.
Do not use AMISTOP if you notice any visible signs of deterioration.
Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines no longer required.
These measures will help to protect the environment.