Properties: Apihist contains antazoline phosphate which has antiallergic effects by competitive blocking of the H1 receptors of the effector cells, thus the vascular permeability and expansion are reduced.
Apihist also contains naphazoline HCl which acts as a local vasoconstrictor so it eliminates inflammatory irritation of the conjunctiva or relieves the nasal congestion.
Indications: - As ophthalmic drops: Apihist is indicated in the treatment of irritant
conjunctivitis and also in allergic inflammatory conditions of the conjunctiva.
- As nasal drops: Apihist is used for relief of nasal congestion.

Contraindications: Apihist should not be used in patients with narrow-angle glaucoma, hypersensitivity to any component of the formula or with soft contact lenses. Apihist shouldn't be used for infants.

Precaution: A severe hypertensive crisis may ensue in patients under MAO inhibitor medication from use of sympathomimetic drugs. CNS depression leading to coma and marked reduction in body temperature may occur in children, especially infants.

Dosage: - As ophthalmic drops: 1-2 drops of Apihist is instilled in each eye three to four times daily.
- As nasal drops: For adults: Instill 1-2 drops into each nostril every 3 or 4 hours.

Prolonged use of Apihist as nasal drops may cause a rebound congestion that stimulates the condition for which it was employed originally.

Store between 15-25 °C, protect form light and discard the bottle one month after opening.