1- What Defopan is and what it is used for
Defopan is grape-anise flavored Hyoscine – N – butylbromide syrup. Hyoscine – N –
butylbromide is antispasmodic with anti-muscarinic activity
Defopan is used to relieve cramps in the muscles of your:
• Stomach
• Gut (intestine)
• Bladder and the tubes that lead to the outside of your body (urinary system).
It can also be used to relieve the symptoms of Irritable Bowel Syndrome (IBS)

2- Before you take Defopan
A-Do not take Defopan:
Don’t take this medicine if:
You are allergic (to hyoscine – N – butylbromide or any components of the drug
Or have any of the following conditions:
- Enlarged prostate gland.
- Glaucoma.
- Megacolon.
- Myasthenia gravis.
- Pregnant, likely to get pregnant, or are breast-feeding.
B-Take special care with DEFOPAN
Please tell your physician or pharmacist before taking Defopan if
- You have heart failure, or tachycardia.
- You have kidney or liver problems.
- You have an overactive thyroid.
- You are elderly.
- You have difficulty in urinating.
- You have constipation.
- You have a fever.
C-Taking other medicines, herbal or dietary supplements
Defopan may interact with the following medicines:
- Antihistamines.
- Tricyclic antidepressants and antipsychotic drugs.
- Antiarrhythmic." quinidine or disopyramide".
- Beta 2 adrenergic," salbutamol for asthma".
- Bronchodilators,"Ipratropium,Tritropium".
- Metoclopramide.
- Amantadine (an antiviral).
Please tell your physician or pharmacist if you are taking or have recently taken any
other medicines, including medicines obtained without prescription.
D-Taking DEFOPAN with food and drink
DEFOPAN can be taken by mouth with or without food.
E-Pregnancy
Pregnancy risk factor for Defopan is (Category C).
It should be given only if the potential benefit outweighs the potential risk to the fetus.
F-Breastfeeding
No information is available on the use of DEFOPAN during breastfeeding. Long-term
use of Defopan might reduce milk production, but a single dose is unlikely to interfere
with breastfeeding.
G- Driving and using machines
Temporary blurred vision may occur which may affect on the ability to drive or using
machine.
H- Important information about some of the ingredients of Defopan:
E420 which may have a mild laxative effect.

3- How to take Defopan
Always take Defopan syrup exactly as your physician has told you. You should check
with your physician or pharmacist if you are not sure.
DEFOPAN Syrup should not be taken continuously for long periods of time.
How much to take
Adults and children over 12 years
Dimensions : 190 x 170 mm
Pantone Color : Black
GSM :
Pharma code : 89
Font Arabic : Winsoft Pro
Font English : Winsoft Pro
Initiator : Reg
Last update : 14 / 01 / 2015
Changes : Change to PIL
Market: Domestic
- The usual dose is 20 ml 4 times a day.
- For Irritable Bowel Syndrome, your doctor may give you a lower starting dose of 10
ml 3 times a day. This dose may be increased, if further relief is necessary.
Children 6 - 12 years:
- The usual dose is 10 ml 3 times a day.
DEFOPAN is not recommended for children under 6 years.
If you take more DEFOPAN Syrup than you should
If you take more DEFOPAN Syrup than you should, talk to a doctor or go to a hospital
straight away. Take the medicine pack with you.
If you forget to take DEFOPAN Syrup
- If you forget a dose, take it as soon as you remember. However, if it is time for the
next dose, skip the missed dose.
- Do not take a double dose to make up for a forgotten dose

4- POSSIBLE SIDE EFFECTS
Like all medicines, DEFOPAN Syrup can cause side effects, although not everybody
gets them. The following side effects may happen with this medicine.
Stop taking your medicine and see a doctor straight away if you notice any of the
following serious side effects:
- Allergic reactions such as skin reactions e.g. nettle rash, itching (affects fewer than
1 in 100 people), rash, redness of the skin.
- Severe allergic reactions (anaphylactic shock) such as difficulty breathing, feeling
faint or dizzy (shock).
- Painful red eye with loss of vision.
Other side effects
- Dry mouth (affects fewer than 1 in 100 people).
- Small blisters on hands and feet (affects fewer than 1 in 100 people).
- Increased heart rate (affects fewer than 1 in 100 people).
- Being unable to pass water (urine) (affects fewer than 1 in 1,000 people).
If any of the side effects gets troublesome or serious, or if you notice any side effects
not listed in this leaflet, tell your doctor or pharmacist.

5- How to store Defopan
Keep out of reach and sight of children.
To be used within one month after first opening.
Do not store above 30°C.
Store in the original container.
Do not use Defopan after the expiry date which is stated on the box. The expiry date
refers to the last day of that month.
Do not use Defopan if you notice any visible signs of deterioration.
Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help
to protect the environment.