Dextran 40 In Normal Saline Infusion is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

·         Vascular thrombosis

·         Von willebrand disease

·         Hypovolemia

·         Low sodium levels

·         Low potassium levels

·         Low magnesium levels

·         Low calcium levels

·         Blood and fluid loss

Intravenous Infusion:

Recommended flow rate: 15 - 70 drops/minute/70 kg BW.

Maximum dosage: initially 500 - 1000 ml can be given & further doses are given according to patient’s condition.

Note:

The first 20 ml should be injected slowly and under careful observation due to the possibility of Anaphylactoid reactions.

§ Plasma substitutes should be used with caution in patients with cardiac disease or renal impairment. Urine output should be monitored.

§ Care should be taken to avoid haematocrit concentration from falling below 25 – 30% and the patient should be monitored for hypersensitivity reactions.

§ Do not use if leakage was found, solution is cloudy or contains particles.

§ Do not expose the solution to undue temperature fluctuation.

No untoward interactions have been reported.

Not available.

Not available.

§ Hypersensitivity reactions may occur including rarely, severe anaphylactoid reactions.

§ Transient increase in bleeding time may occur.

§ Volume overload which may lead to pulmonary

§ Cerebral oedema

§ Platelet dysfunction

§ Acute renal failure

§ Bleeding

§ Nausea

§ Nasal congestion

§ Allergic reactions

Abdominal pain

Not available.

ATC Codes: B05AA05

It is reported that dextran presents an effect on the hemostatic system in particular by prolonging bleeding time. In the same trials, dextran is reported to reduce emboli, reduce platelet adhesiveness and produce hemodilution. These effects have been showed to be greater proportionally with the increase in the molecular weight of the dextran.

Absorption: Administered I.V. Plasma level depends on rate of infusion and rate of disappearance of drug from plasma.
Distribution: Distributed throughout vascular system.
Metabolism: Dextran molecules with molecular weights above 50,000 are enzymatically degraded by dextrinase to glucose at about 70 to 90 mg/kg daily. Process is variable.
Excretion: Dextran 1 is rapidly and completely excreted by glomerular filtration. Dextran molecules with molecular weights below 50,000 are eliminated by renal excretion, with 40% of dextran 70 appearing in urine within 24 hours. About 50% of dextran 40 excreted in urine within 3 hours, 60% within 6 hours, and 75% within 24 hours. Remaining 25% is hydrolyzed partially and excreted in urine, excreted partially in feces, and partially oxidized.

Not available.

None known.

·   Keep in a safe place, out of the reach and sight of children.

·   Store below 25º C.

Bottle size: 500 ml × 10 Bottles

Sterile, pyrogen free.

Polyethylene granules:

White colored, round to oblong shaped granules, which are used for the production of containers for intravenous solutions.

Discard after single use.

Discard any unused portion.

Do not reconnect partially used bottles.

1. Opening

a. If leaks are found, discard solution, as sterility may be impaired.

b. Check the solution for limpidity and absence of foreign matters. If solution is not clear or contains foreign matters, discard the solution.

2. Preparation for administration

Use sterile material for preparation and administration.

a. Suspend container from eyelet support.

b. Remove plastic protector from outlet port at bottom of container

c. Use an aseptic method to set up the infusion

d. Attach administration set. Refer to complete directions accompanying set for connection, priming of the set and administration of the solution.