Xolamol  eye drops are a combination of two
medicines: dorzolamide and timolol.
• Dorzolamide belongs to a group of medicines
called "carbonic anhydrase inhibitors".
• Timolol belongs to a group of medicines called
"beta blockers".
Xolamol  eye drops are prescribed to lower
raised pressure within the eye in the treatment of
glaucoma when beta-blocker eye drops used alone
are not adequate.

 Do not use XolamolTM eye drops if you are
allergic to dorzolamide or timolol, beta blockers or
any of the other ingredients of this medicine
(listed in section 6).
• have now or have had in the past respiratory
problems such as asthma, severe chronic
obstructive lung disease (severe lung disease
which may cause wheeziness, difficulty in
breathing and/or long-standing cough).
• have severe kidney problems, or a prior history
of kidney stones.
• have a disturbance in the pH (acid /alkali
balance) of your blood.
• have certain heart problems,including certain
heart rhythm disturbances producing an
abnormally slow heart rate or severe heart failure.
If you think any of these apply to you, do not use
XolamolTM eye drops until you have consulted
your doctor. 

Take special care with XolamolTM eye drops
Before you use this medicine, tell your doctor if
you have now or have had in the past.
• coronary heart disease (symptoms can include
chest pain or tightness, breathlessness or choking),
Prinzmental’s angina (chest pain while resting),
heart failure, low blood pressure.
• disturbances of heart rate such as slow heart beat.
• breathing problems, asthma or chronic
obstructive pulmonary disease.
• poor blood circulation disease (such as
Raynaud's disease or Raynaud's syndrome)
• diabetes as XolamolTM eye drops may mask signs
and symptoms of low blood sugar.
• over activity of the thyroid gland as XolamolTM
eye drops may mask signs and symptoms.
• liver problems, if you have muscle weakness
or have been diagnosed as having myasthenia
gravis.
• any allergies to a medicine you have taken.
If you develop conjunctivitis (redness and
irritation of the eyes), swelling of the eye or
eyelids, skin rash or itching in and around the eye
contact your doctor immediately. Such
symptoms may be due to an allergic reaction or
may be a side-effect of XolamolTM eye drops (See
‘Possible Side Effects’).
Tell your doctor if you develop an eye infection,
receive an eye injury, have eye surgery, develop
other reactions or worsening of symptoms.
If you wear soft contact lenses, it is important
that your lenses are removed before using your
eye drops and not put back into your eyes until
15 minutes after using your eye drops as the
preservative benzalkonium chloride may possibly
discolour the contact lenses.
Before surgery and anaesthesia (even at the
dentist), tell your doctor or dentist that you are
using XolamolTM eye drops, as this medicine may
change effects of some medicines used during
anaesthesia and there may be a sudden fall in
blood-pressure associated with the anaesthetic.
Use in children
There is limited experience with XolamolTM eye
drops in infants and children.
Use in elderly
In studies with XolamolTM eye drops, the effects of
XolamolTM eye drops were similar in both elderly
and younger patients.
Using other medicines
XolamolTM eye drops can affect or be affected by
other medicines you are using, including other eye
drops for the treatment of glaucoma. Tell your
doctor or pharmacist if you are taking, have
recently taken or might take any other medicines,
including medicines obtained without a
prescription. This is particularly important if any
of the following apply to you:
• You are taking antihypertensive medicines which
are used to lower high blood pressure or medicines
to treat heart disease such as calcium channel
blockers and ß-blockers or digoxin.
• You are taking medicines to treat a disturbed or
uneven heartbeat such as quinidine or digoxin.
• You are using another eye drop that contains a
ß-blocker.
• You are taking another carbonic anhydrase
inhibitor such as acetazolamide. You may be
taking this type of medicine by mouth, as eye
drops, or by some other method.
• You are taking quinidine (used to treat heart
conditions and some types of malaria).
• You are taking monoamine oxidase inhibitors
(MAOIs) or selective serotonin re uptake
inhibitors (SSRIs) (such as fluoxetine and
paroxetine) both of which are used to treat
depression or another illness.
• You are taking a parasympathomimetic medicine
which may have been prescribed to help you pass
urine. Para sympathomimetics are also a particular
type of medicine which are sometimes used to
help restore normal movements through the bowel.
• You are taking narcotics such as morphine used
to treat moderate to severe pain or if you are
taking large doses of aspirin. Although there is no
evidence that dorzolamide hydrochloride interacts
with aspirin, some other medicines which are
related to dorzolamide hydrochloride and which
are taken by mouth, have been known to interact
with aspirin.
• You are taking medicines to treat diabetes or
high blood sugar.
• You are taking epinephrine (adrenaline).
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking this medicine.
Do not use XolamolTM eye drops if you are
pregnant unless your doctor considers it necessary.
Do not use XolamolTM eye drops if you are
breast-feeding. Timolol may get into your milk.
Driving and using machines
XolamolTM eye drops may cause side effects such
as blurred vision in some patients. Do not drive or
use any tools or machines until the symptoms have
cleared.
Important information about some of the
ingredients of XolamolTM eye drops
XolamolTM eye drops contain the preservative
benzalkonium chloride.
• Benzalkonium chloride may cause eye irritation.
• Benzalkonium chloride is known to discolour
soft contact lenses. Avoid contact with soft contact
lenses. Remove contact lenses prior to application
and wait until 15 minutes before re-insertion.

Always use XolamolTM eye drops exactly as your
doctor has told you. You should check with your
doctor or pharmacist if you are not sure.
The appropriate dosage and duration of treatment
will be established by your doctor.
The usual dose is one drop in the affected eye(s)
two times a day, for example in the morning and
in the evening.
If you use XolamolTM eye drops with another eye
drop, leave at least 10 minutes between putting in
XolamolTM eye drops and the other medicine.
Do not change the dosage of the drug without
consulting your doctor. If you must stop treatment,
contact your doctor immediately.
Instructions for using eye drops:
• Unscrew the cap from the bottle, check the
dropper is clean.
• Pull your lower eyelid gently down, and then
carefully instil one drop inside the lower eyelid, in
the corner closest to the nose.
• Release the lower eyelid, and blink a few times
to make sure the eye is covered by the liquid.
• If you use drops in both eyes, repeat the steps for
your other eye.
• Put the bottle cap back on firmly immediately
after use.
If you use more XolamolTM eye drops than you
should
It is important to keep to the dose your doctor has
prescribed. If you put too many drops in your eye
or swallow any of the contents of the bottle, you
may feel unwell, for example you may become
light-headed, have difficulty breathing, or feel that
your heart rate has slowed. If you feel any of the
above effects you should seek medical attention
immediately.

If you forget to use XolamolTM eye drops

It is important to use XolamolTM eye drops as
prescribed by your doctor.
If you miss a dose, apply it as soon as possible.
However,if it is almost time for the next dose,
skip the missed dose and go back to your regular
dosing schedule.
Do not use a double dose to make up for forgotten
individual doses.
If you stop taking XolamolTM eye drops
If you want to stop using this medicine talk to
your doctor first.
If you have any further questions on the use of
this product, ask your doctor or pharmacist.

Like all medicines, XolamolTM eye drops can
cause side effects, although not every body gets
them.
You can usually carry on taking the drops, unless
the effects are serious. If you're worried, talk to a
doctor or pharmacist. Do not stop using
XolamolTM without speaking to your doctor.
If you experience any of the following serious
side effects, stop using this medicine and tell
your doctor immediately or go to the nearest
hospital accident and emergency department.
• Generalized allergic reactions including swelling
beneath the skin that can occur in areas such as the
face and limbs, and can obstruct the airway which
may cause difficulty swallowing or breathing,
hives or itchy rash, localized and generalized rash,
itchiness, severe sudden life-threatening allergic
reaction.
• Serious illness with severe peeling and swelling
of the skin, blistering of the skin, mouth, eyes
genitals and fever. Skin rash with pink-red
blotches especially on palms of hands or soles of
feet which may blister.
Like other medicines applied into eyes,
XolamolTM eye drops are absorbed into the blood.
This may cause similar side effects as seen with
intravenous and/or 'oral' beta-blocking agents.
Incidence of side effects after topical ophthalmic
administration is lower than when medicines are,
for example, taken by mouth or injected.
The following side effects may be seen with
XolamolTM eye drops or one of its components:
Very Common (affects more than 1 user in 10):
Burning and stinging of the eyes, unusual taste.
Common (affects 1 to 10 users in 100):
Redness in and around the eye(s), watering or
itching of the eye(s), and effects on the surface
of the eye(s), swelling and/or irritation in and
around the eye(s), feeling of having something
in the eye (corneal erosion), decreased corneal
sensitivity (not realising of getting something in
the eye and not feeling pain), eye pain, dry eyes,
blurred vision, headache, sinusitis (feeling of
tension or fullness in the nose), feeling sick, also
called nausea, and fatigue.
Uncommon (affects 1 to 10 users in 1,000):
Dizziness, depression, inflammation of the iris,
blurred vision (in some cases due to withdrawal of
medication to treat excessive contraction of the
pupil of the eye) , slow heartbeat, fainting, labored
breathing, indigestion, and kidney stones (often
marked by a sudden onset of excruciating,
cramping pain in their low back and/or side, groin,
or abdomen).
Rare (affects 1 to 10 users in 10,000):
Systemic lupus erythematosus (an immune disease
which may cause an inflammation of internal
organs), tingling or numbness of the hands or feet,
trouble sleeping, nightmares, memory loss,
weakening of the muscles, decreased sex drive,
stroke, temporary short sightedness which may
resolve when treatment is stopped, development
of fluid under the retina (choroidal detachment
following filtration surgery), drooping of the
eyelids, double vision, eyelid crusting, swelling of
the cornea (with symptoms of visual
disturbances), low pressure in the eye, ringing
noises in your ear, low blood pressure, irregular
heartbeat, chest pain, palpitations (a quicker
and/or irregular heartbeat), oedema (fluid build
up), heart attack, congestive heart failure (heart
disease with shortness of breath and swelling of
the feet and legs due to fluid build up), reduced
blood flow to the brain, swelling or coldness of
your hands and feet and reduced circulation in
your arms and legs, leg cramps and/or leg pain
when walking (claudication), shortness of breath,
feeling out of breath, runny or stuffed nose, nose
bleed, difficulty in breathing, cough, throat
irritation, dry mouth, diarrhoea, contact
dermatitis, hair loss, psoriasis or worsening of
psoriasis, Peyronie's disease (which may cause a
curvature of the penis), weakness/tiredness,
allergic type reactions such as rash, hives, itching,
in rare cases possible swelling of the lips, eyes
and mouth, wheezing.
Frequency unknown:
Low blood glucose levels, heart failure, stomach
pain and vomiting, muscle pain not caused by
exercise, sexual dysfunction and decreased libido.
If any of the side effects gets serious, or if you
notice any side effects not listed in this leaflet.
please tell your doctor or pharmacist, particularly
if you experience any changes/visual disturbance
when using XolamolTM eye drops after eye
surgery.

Keep out of the reach and sight of children.
• Do not store above 30 ºC.
• Do not use Xolamol™ after the expiry date
which is stated on the bottle and the carton after
‘Exp’.
• Xolamol™ eye drops are sterile when first
opened, it is important to keep the drops as clean
as possible during use.
• Discard after 30 days of opening the bottle.
• Medicines should not be disposed of via waste
water or household waste. Ask your pharmacist
how to dispose of medicines no longer required.
This will help protect the environment.