CeeCal^® Sugar Free is multivitamin dietary supplement.

For oral administration only.

For adults and children 12 years and above: take one tablet daily dissolved in a glass of water or as directed by the doctor.

Pregnant, nursing women and patients with renal disorders to take this product by doctor prescription. Consult your doctor before using this product.

Do not use this product for long term use.

Do not take this product with other products containing the same active ingredients.

D not exceed recommended dosage. Incase of overdose, seek doctor assistant.

It is preferred to take vitamins and minerals from its natural sources.

Keep out of the reach of children.

Do not take this product with other products containing the same active ingredients.

Pregnant and nursing women to take this product by doctor prescription.

None.

Provided the dosage recommendations are observed, no side effects are to be expected.

To reports any side effect (s):

Do not exceed recommended dosage. Incase of overdose, seek doctor assistant.

Strong evidence that supplemental Calcium and vitamin D3 can reduce the incidence of hip and other non-vertebral fractures derives from an 18 month randomised placebo controlled study in 3270 healthy elderly women living in nursing homes or apartments for elderly people. A positive effect on bone mineral density was also observed.

In patients treated with 1200mg elemental Calcium and 800IU vitamin D3 daily, i.e. the same dose delivered by the twice daily administration of two Adcal-D3 Caplets, the number of hip fractures was 43% lower (p=0.043) and the total number of non-vertebral fractures was 32% lower than among those who received placebo. Proximal femur bone mineral density after 18 months of treatment increased 2.7% in the Calcium / vitamin D3 group and decreased 4.6% in the placebo group (p<0.001). In the Calcium / vitamin D3 group, the mean serum PTH concentration decreased by 44% from baseline at 18 months and serum 25-hydroxy-vitamin D concentration had increased by 162% over baseline.

Analysis of the intention-to-treat results showed a decreased probability of both hip fractures (p=0.004) and other fractures (p < 0.001) in the Calcium / vitamin D3 treatment group.

Analysis of the other two populations (active treatment and those treated and followed for 18 months) revealed comparable results to the intention-to-treat analysis. The odds ratio for hip fractures among women in the placebo group compared with those in the Calcium / vitamin D3 group was 1.7 (95% CI 1.0 to 2.8) and that for other no vertebral fractures was 1.4 (95% CI 1.4 to 2.1). In the placebo group, there was a marked increase in the incidence of hip fractures over time whereas the incidence in the Calcium / vitamin D3 group was stable.

Thus treatment reduced the age-related risk of fracture at 18 months (p = 0.007 for hip fractures and p = 0.009 for all non-vertebral fractures). At 3 years follow-up, the decrease in fracture risk was maintained in the calcium/vitamin D3 group.

The substances needed by the body for its growth, maintenance and energy requirements can be utilized only if vitamins and minerals are ingested in addition to proteins, fats and carbohydrates. There is an important interdependency between the metabolism of vitamins C, B6, D and Calcium, particularly in bone formation: Calcium is the mineral most closely associated with vitamin metabolism.

The pharmacokinetic profiles of Calcium and its salts are well known. Calcium carbonate is converted to Calcium chloride by gastric acid. Calcium is absorbed to the extent of about 15-25% from the gastro-intestinal tract while the remainder reverts to insoluble Calcium Carbonate and calcium stearate, and is excreted in the faeces.

The pharmacokinetics of vitamin D is also well known. vitamin D is well absorbed from the gastro-intestinal tract in the presence of bile. It is hydroxylated in the liver to form 25-hydroxycholecalciferol and then undergoes further hydroxylation in the kidney to form the active metabolite 1, 25 dihydroxycholecalciferol (calcitriol). The metabolites circulate in the blood bound to a specific α - globin. vitamin D and its metabolites are excreted mainly in the bile and faeces.

Calcium Carbonate and vitamin D are well known and widely used materials and have been used in clinical practice for many years. As such, toxicity is only likely to occur in chronic overdosage where hypercalcaemia could result.

Citric Acid

Mannitol

L-Leucine

Sodium Saccharine

Sodium Bicarbonate

Sodium Chloride

Povidone

Orange Flavour

Sunset Yellow Dye

Not applicable.

Store in a dry place below 30 °C. 

Close container tightly after use.

Keep out of the reach of children.

Primary packaging: HDPE Cylindrical Tube.

Secondary packaging: Printed cardboard case containing the tube and the package insert.

Dissolve one tablet in a glass of water.