This medicine belongs to a group of medicines called muscle relaxants. The full name of this medicine is Traxia^® solution for injection/infusion but for ease of reference it will be referred to as Traxia^® throughout the leaflet. 

Traxia^® is used 

• During surgery and other procedures and in intensive care 

• With general anaesthesia, or sedation in the Intensive Care Unit to relax muscles 

• To help insert a tube into the windpipe (tracheal intubation) if a person needs help to breathe (with or without a machine). 

Traxia^® is used in adults and in children over 1 month of age. 

Do not use Traxia^® 

• If you are allergic (hypersensitive) to cisatracurium besylate, atracurium, or any of the ingredients in this medicine (listed in section 6) 

Warnings and Precautions 

Talk to your doctor before using this medicine if you: 

• have a neuromuscular disease, such as a muscle wasting disease, paralysis, motor neurone disease, cerebral palsy or myasthenia gravis 

• have a burn which requires medical treatment 

• have ever had an allergic reaction to any muscle relaxant 

• are aware that you have abnormal blood acidity or abnormal blood electrolyte levels 

Using other medicines and Traxia^® 

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This includes herbal medicines. This is because these medicines can affect how well Traxia^® works or cause side effects. 

In particular tell your doctor, nurse or pharmacist if you are taking, or have recently received any of the following: 

• anaesthetics (used to reduce sensation and pain during surgical procedures) 

• antibiotics (used to treat infections) 

• medicines for uneven heart beats (anti-arrhythmics) 

• medicines for high blood pressure 

• water tablets (diuretics), such as frusemide 

• medicines for inflammation of the joints, such as chloroquine or
d-penicillamine 

• steroids 

• medicines for fits (epilepsy), such as phenytoin or carbamazepine 

• medicines for mental illness, such as lithium, monoamine oxidase inhibitors (MAOIs) or chlorpromazine (which can also be used for nausea) 

• medicines containing magnesium 

• medicines for Alzheimer’s disease (anticholinesterases such as donepezil) 

• other muscle relaxants 

Pregnancy and breast-feeding 

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine. 

You should not be given this medicine if you are pregnant. 

If you are breast-feeding and you are given this medicine because of a medical emergency, ask your doctor for advice before starting breast-feeding again. Breast-feeding may be started 12 hours after this medicine has been given to you. 

Driving and using machines 

Some patients may occasionally feel dizzy, drowsy or confused after treatment with this medicine. If this happens to you, do not drive or use machinery. Your doctor will advise how long you should wait after an operation before you can drive. 

Traxia^® will be administered to you by a healthcare professional. 

This medicine will only be administered directly into a vein, either by injection or by slow intravenous infusion. Traxia^® can be given as a single injection into your vein (intravenous bolus injection) or as a continuous infusion into your vein. This is where the drug is slowly given to you over
a longer period of time. 

Your doctor will decide how you are given this medicine and the dose you will receive. This depends on the following factors: 

• your body weight 

• the amount and duration of muscle relaxation required 

• your expected response to the medicine. 

Use in Children 

Children less than 1 month old should not be given this medicine. 

If you receive more Traxia^® than you should 

This medicine will always be given by your doctor or anaesthetist under carefully controlled conditions. It is unlikely that you will be given too much, however, tell your doctor or nurse if you have any concerns. 

Like all medicines, this medicine can cause side effects, although not everybody gets them. 

Allergic reactions (may affect up to 1 in 10,000 people) 

• If you have an allergic reaction, tell your doctor or nurse straight away. The signs may include: 

• sudden wheeziness, chest pain or chest tightness 

• swelling of your eyelids, face, lips, mouth or tongue 

• a lumpy skin rash or ‘hives’ anywhere on your body 

• a collapse 

The following side effects have been reported following the administration of this medicine: 

Common (may affect up to 1 in 10 people): 

• decreased heart rate 

• low blood pressure 

Uncommon (may affect up to 1 in 100 people): 

• a rash or redness on your skin 

• coughing or wheezing 

Very rare (may affect up to 1 in 10,000 people): 

• muscle wasting and muscle weakness 

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Store in a refrigerator between 2 – 8°C. Do not freeze. protect from light. 

To be used only if the solution appears clear & colorless. The product should be visually inspected before use, and if the visual appearance differs from the above description or if the container is damaged, the product must be discarded. 

Unused portions of opened vials must not be stored for later use. 

Diluted solutions should be used immediately, however, if this is not possible they can, in certain circumstances, be stored for up to 24 hours. 

Do not throw away any medicines via wastewater or household waste. Your doctor or nurse will throw away any medicine that is no longer required. These measures will help to protect the environment.